tdbR00000269
| Name | Value |
|---|---|
| Coding AA: | Leu |
| Anticodon sequence: | .AA |
| Organism: | Homo sapiens NCBI:txid9606 |
| RNA type: | cytoplasmic |
| Sequence: | GUCAGLAUGLCMGAGUGGDCPAAGGCRCCAGACU.AAKPPCUGGJCPCCGGAUGGAG?GUGGGTPCG"AUCCCACUUCUGACACCA |
| Unmodified sequence: | GUCAGGAUGGCCGAGUGGUCUAAGGCGCCAGACUAAAGUUCUGGUCUCCGGAUGGAGCGUGGGUUCGAAUCCCACUUCUGACACCA |
| Secondary structure: | (((((((..(((...........)))((((((.......)))))).............(((((.......)))))))))))).... |
| Homology model or structure extracted from PDB: |
Model Download (by RNA Composer) (last update July 2, 2025) |
| Prepared by: | Database creators |
| Version: | 2 (Oct. 4, 2024), created: Feb. 25, 2019, modified: June 29, 2026 |
| Folding free energy [kcal/mol]: | -26.50 |
| Pre-aligned sequence: Pre-aligned secondary structure: |
-GUCAGLAUGLCMGAGU--GGDCPAAGGCRCCAGACU.AAKPPCUGGJ-CPCCG--GA-----UGGAG--?GUGGGTPCG"AUCCCACUUCUGACACCA .(((((((..(((.............)))((((((.......)))))).......................(((((.......)))))))))))).... |
| Publications: |
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| Previous entry: | tdbR00000269 (Oct. 4, 2024, 2:53 p.m.) |
Aminoacylation
| Name | Value |
|---|---|
| Positive identity elements regulating aminoacylation: | A73; class-II tRNA tertiary/variable-arm context; D/T-loop interactions |
| Negative identity elements antideterminants of aminoacylation: | A73->G73 can switch human tRNALeu toward Ser acceptance. |
| Citation: | Metzger,A.U., Heckl,M., Willbold,D., Breitschopf,K., RajBhandary,U.L., R¨osch,P. and Gross,H.J. (1997) Structural studies on tRNA acceptor stem microhelices: exchange of the discriminator base A73 for G in human tRNALeu switches the acceptor specificity from leucine to serine possibly by decreasing the stability of the terminal G1–C72 base pair. Nucleic Acids Res., 25, 4551–4556. |
| DOI: | 10.1093/nar/25.22.4551 |
| PMID: | 9358165 |
Secondary structure
Tertiary structure
Model based on: