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tdbR00000009

NameValue
Coding AA: Ala
Anticodon sequence: VGC
Organism: Escherichia coli NCBI:txid562
RNA type: cytoplasmic
Sequence: GGGGGCA4AGCUCAGCDGGGAGAGCGCCUGCUUVGCACGCAGGAG7UCUGCGGTPCGAUCCCGCGCGCUCCCACCA
Unmodified sequence: GGGGGCAUAGCUCAGCUGGGAGAGCGCCUGCUUUGCACGCAGGAGGUCUGCGGUUCGAUCCCGCGCGCUCCCACCA
Secondary structure: ((((((...((((........)))).(((((.......))))).....(((((.......))))).))))))....
Homology model or
structure extracted from PDB:		 Model Download (by Moderna) Download (by RNA Composer) (last update July 2, 2025)
Prepared by: Database creators
Version: 1 (Sept. 6, 2019), created: Feb. 25, 2019, modified: June 29, 2026
Folding free energy [kcal/mol]: -29.70
Pre-aligned sequence:
Pre-aligned secondary structure:		 -GGGGGCA4AGCUCAGCD-GGG--AGAGCGCCUGCUUVGCACGCAGGAG-------------------7UCUGCGGTPCGAUCCCGCGCGCUCCCACCA
.((((((...((((...........)))).(((((.......)))))........................(((((.......))))).))))))....
Publications:
  • Primary structure of E. coli alanine transfer RNA: relation to the yeast phenylalanyl tRNA synthetase recognition site.
    R J Williams, W Nagel, B Roe, B Dudock
    Biochemical and biophysical research communications
    volume: 60 issue: 4 date: Oct. 23, 1974 PUBMED ID: 4607604
Comments: 8 PARTIALLY MODIFIED

Aminoacylation

NameValue
Positive identity elements regulating aminoacylation: A73; G2-C71; G3-U70; G4-C69; G20
Negative identity elements antideterminants of aminoacylation: G3-U70 also functions as a negative/orthogonalizing element against some non-Ala systems; in yeast ThrRS context, G3-U70 in tRNAAla acts as an antideterminant for ThrRS.
Citation: Choi,H., Otten,S. and McClain,W.H. (2002) Isolation of novel tRNAAla mutants by library selection in a tRNAAla knockout strain. Biochimie, 84, 705–711.
DOI: 10.1016/S0300-9084(02)01407-4
PMID: 12457558

Secondary structure

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Tertiary structure

Model based on:
Moderna
RNA Composer