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tdbR00000595

NameValue
Coding AA: Leu
Anticodon sequence: BAA
Organism: Escherichia coli NCBI:txid562
RNA type: cytoplasmic
Sequence: GCCGAAG4GGCGAAADC#GDAGACACAGUUGAPUBAA*APCAACCGUAGAAAUACGUGCCGGTPCGAGUCCGGCCUUCGGCACCA
Unmodified sequence: GCCGAAGUGGCGAAAUCGGUAGACACAGUUGAUUCAAAAUCAACCGUAGAAAUACGUGCCGGUUCGAGUCCGGCCUUCGGCACCA
Secondary structure: (((((((..(.(...........).).(((((.......))))).............(((((.......))))))))))))....
Homology model or
structure extracted from PDB:		 Model Download (by Moderna) Download (by RNA Composer) (last update July 2, 2025)
Prepared by: Database creators
Version: 1 (Sept. 6, 2019), created: Feb. 25, 2019, modified: June 29, 2026
Folding free energy [kcal/mol]: -19.30
Pre-aligned sequence:
Pre-aligned secondary structure:		 -GCCGAAG4GGCGAAADC-#GDA-GACACAGUUGAPUBAA*APCAACC-GUA----GAAA-----UACG-UGCCGGTPCGAGUCCGGCCUUCGGCACCA
.(((((((..(.(.............).).(((((.......)))))........................(((((.......))))))))))))....
Publications:
  • Modified nucleosides in the first positions of the anticodons of tRNA(Leu)4 and tRNA(Leu)5 from Escherichia coli.
    N Horie, Z Yamaizumi, Y Kuchino, K Takai, E Goldman, T Miyazawa, S Nishimura, S Yokoyama
    Biochemistry
    volume: 38 issue: 1 date: Jan. 5, 1999 PUBMED ID: 9890900

Aminoacylation

NameValue
Positive identity elements regulating aminoacylation: A73; A15-U48; G18; G19; A20a; D/T-loop tertiary interactions G18:U55, G19-C56, U54:A58; long variable arm/framework context
Negative identity elements antideterminants of aminoacylation: NA
Citation: Du,X. and Wang,E.-D. (2003) Tertiary structure base pairs between D- and TpsiC-loops of Escherichia coli tRNALeu play important roles in both aminoacylation and editing. Nucleic Acids Res., 31, 2865–2872.
DOI: 10.1093/nar/gkg382
PMID: 12771213

Secondary structure

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Tertiary structure

Model based on:
Moderna
RNA Composer