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tdbR00000428

NameValue
Coding AA: Ser
Anticodon sequence: UGA
Organism: Homo sapiens NCBI:txid9606
RNA type: cytoplasmic
Sequence: GUAGUCGUGGCMGAGD#GDDAAGGCGAPGGACUUGAAAPCCAUJGGGGU'UCCCCG?GCAGGTPCG"AUCCUGCCGACUACGCCA
Unmodified sequence: GUAGUCGUGGCCGAGUGGUUAAGGCGAUGGACUUGAAAUCCAUUGGGGUCUCCCCGCGCAGGUUCGAAUCCUGCCGACUACGCCA
Secondary structure: (((((((..(((..........)))((((((.......)))))).............(((((.......))))))))))))....
Homology model or
structure extracted from PDB:		 Model Download (by Moderna) Download (by RNA Composer) (last update July 2, 2025)
Prepared by: Database creators
Version: 1 (Sept. 6, 2019), created: Feb. 25, 2019, modified: June 29, 2026
Folding free energy [kcal/mol]: -25.90
Pre-aligned sequence:
Pre-aligned secondary structure:		 -GUAGUCGUGGCMGAGD--#GDD-AAGGCGAPGGACUUGAAAPCCAUJ-GGGG---U'U-----CCCCG-?GCAGGTPCG"AUCCUGCCGACUACGCCA
.(((((((..(((.............)))((((((.......)))))).......................(((((.......))))))))))))....
Publications:
  • Amber, ochre and opal suppressor tRNA genes derived from a human serine tRNA gene.
    J P Capone, P A Sharp, U L RajBhandary
    The EMBO journal
    volume: 4 issue: 1 PUBMED ID: 2990894

Aminoacylation

NameValue
Positive identity elements regulating aminoacylation: G73; large variable arm
Negative identity elements antideterminants of aminoacylation: Anticodon is not a major determinant.
Citation: Achsel,T. and Gross,H.J. (1993) Identity determinants of human tRNASer: sequence elements necessary for serylation and maturation of a tRNA with a long extra arm. EMBO J., 12, 3333–3338.
DOI: 10.1002/j.1460-2075.1993.tb06003.x
PMID: 8344269

Secondary structure

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Tertiary structure

Model based on:
Moderna
RNA Composer