tdbR00000408
| Name | Value |
|---|---|
| Coding AA: | Ser |
| Anticodon sequence: | IGA |
| Organism: | Saccharomyces cerevisiae NCBI:txid4932 |
| RNA type: | cytoplasmic |
| Sequence: | GGCAACUUGGCMGAGD#GDDAAGGCRAAAGAPUIGA+APCUUUJGGGCUUUGCCCG?GCAGGTPCGAGUCCUGCAGUUGUCGCCA |
| Unmodified sequence: | GGCAACUUGGCCGAGUGGUUAAGGCGAAAGAUUAGAAAUCUUUUGGGCUUUGCCCGCGCAGGUUCGAGUCCUGCAGUUGUCGCCA |
| Secondary structure: | (((((((..(((..........)))((((((.......)))))).............(((((.......)))))))))))).... |
| Homology model or structure extracted from PDB: |
Model Download (by Moderna) Download (by RNA Composer) (last update July 2, 2025) |
| Prepared by: | Database creators |
| Version: | 1 (Sept. 6, 2019), created: Feb. 25, 2019, modified: June 29, 2026 |
| Folding free energy [kcal/mol]: | -21.50 |
| Pre-aligned sequence: Pre-aligned secondary structure: |
-GGCAACUUGGCMGAGD--#GDD-AAGGCRAAAGAPUIGA+APCUUUJ-GGGC---UUU-----GCCCG-?GCAGGTPCGAGUCCUGCAGUUGUCGCCA .(((((((..(((.............)))((((((.......)))))).......................(((((.......)))))))))))).... |
| Publications: |
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Aminoacylation
| Name | Value |
|---|---|
| Positive identity elements regulating aminoacylation: | G73; large variable arm; A27-U43 context in some eukaryal tRNAsSer |
| Negative identity elements antideterminants of aminoacylation: | Anticodon is not a major determinant; Pro-anticodon tRNASer variants can remain serylated and cause mistranslation. |
| Citation: | Zimmerman,S.M., Kon,Y., Hauke,A.C., Ruiz,B.Y., Fields,S. and Phizicky,E.M. (2018) Conditional accumulation of toxic tRNAs to cause amino acid misincorporation. Nucleic Acids Res., 46, 7831–7843. |
| DOI: | 10.1093/nar/gky812 |
| PMID: | 30239700 |
Secondary structure
Tertiary structure
Model based on: