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tdbR00000634

NameValue
Coding AA: Ala
Anticodon sequence: HGC
Organism: Homo sapiens NCBI:txid9606
RNA type: cytoplasmic
Sequence: GGGGGAUUAGCUCAAAUGGUAGAGCGCUCGCUUHGCHUGCGAGAGGUAGCGGGAUCGAUGCCCGCAUCCUCCACCA
Unmodified sequence: GGGGGAUUAGCUCAAAUGGUAGAGCGCUCGCUUAGCAUGCGAGAGGUAGCGGGAUCGAUGCCCGCAUCCUCCACCA
Secondary structure: (((((((..((((........)))).(((((.......))))).....(((((.......))))))))))))....
Homology model or
structure extracted from PDB:		 Model Download (by Moderna) Download (by RNA Composer) (last update July 2, 2025)
Prepared by: Database creators
Version: 1 (Sept. 6, 2019), created: May 30, 2019, modified: June 29, 2026
Folding free energy [kcal/mol]: -32.00
Pre-aligned sequence:
Pre-aligned secondary structure:		 -GGGGGAUUAGCUCAAAU-GGU--AGAGCGCUCGCUUHGCHUGCGAGAG-------------------GUAGCGGGAUCGAUGCCCGCAUCCUCCACCA
.(((((((..((((...........)))).(((((.......)))))........................(((((.......))))))))))))....
Publications:
  • Characterizing Expression and Processing of Precursor and Mature Human tRNAs by Hydro-tRNAseq and PAR-CLIP.
    Tasos Gogakos, Miguel Brown, Aitor Garzia, Cindy Meyer, Markus Hafner, Thomas Tuschl
    Cell reports
    volume: 20 issue: 6 date: Aug. 8, 2017 PUBMED ID: 28793268 DOI: 10.1016/j.celrep.2017.07.029
Comments: Sequence obtained from hydro-tRNAseq; modified nucleosides were not determined by MS, only predicted by mismatches frequency; relative abundance among tRNAAla in HEK293 cells: 3.3%

Aminoacylation

NameValue
Positive identity elements regulating aminoacylation: G3-U70
Negative identity elements antideterminants of aminoacylation: NA
Citation: Hou,Y.M. and Schimmel,P. (1989) Evidence that a major determinant for the identity of a transfer RNA is conserved in evolution. Biochemistry, 28, 6800–6804.
DOI: 10.1021/bi00443a003
PMID: 2684266

Secondary structure

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Tertiary structure

Model based on:
Moderna
RNA Composer