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tdbR00000892

NameValue
Coding AA: Leu
Anticodon sequence: VAG
Organism: Escherichia coli NCBI:txid562
RNA type: cytoplasmic
Sequence: GCGGGAGUGGCGAAADD#GUAGACGCACCAGAUUVAGKPUCUGGCGCCGCAAGGUGUGCGAGTPCAAGUCUCGCCUCCCGCACCA
Unmodified sequence: GCGGGAGUGGCGAAAUUGGUAGACGCACCAGAUUUAGGUUCUGGCGCCGCAAGGUGUGCGAGUUCAAGUCUCGCCUCCCGCACCA
Secondary structure: (((((((..(((.........))).(.(((((.......))))).)...........(((((.......))))))))))))....
Homology model or
structure extracted from PDB:		 Model Download (by Moderna) Download (by RNA Composer) (last update July 2, 2025)
Prepared by: Database creators
Version: 1 (Sept. 6, 2019), created: May 30, 2019, modified: June 29, 2026
Folding free energy [kcal/mol]: -22.40
Publications:
  • The wobble hypothesis revisited: uridine-5-oxyacetic acid is critical for reading of G-ending codons.
    S Joakim Näsvall, Peng Chen, Glenn R Björk
    RNA (New York, N.Y.)
    volume: 13 issue: 12 epub: Oct. 17, 2007 PUBMED ID: 17942742

Aminoacylation

NameValue
Positive identity elements regulating aminoacylation: A73; A15-U48; G18; G19; A20a; D/T-loop tertiary interactions G18:U55, G19-C56, U54:A58; long variable arm/framework context
Negative identity elements antideterminants of aminoacylation: NA
Citation: Du,X. and Wang,E.-D. (2003) Tertiary structure base pairs between D- and TpsiC-loops of Escherichia coli tRNALeu play important roles in both aminoacylation and editing. Nucleic Acids Res., 31, 2865–2872.
DOI: 10.1093/nar/gkg382
PMID: 12771213

Secondary structure

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Tertiary structure

Model based on:
Moderna
RNA Composer