| Gene |
Val-AAC, Val-UAC, Val_CAC |
| Disease |
T-cell acute lymphoblastic leukaemia |
| Description |
NOTCH1-induced upregulation of Val tRNA biogenesis enhances protein synthesis and mitochondrial biogenesis |
| tRNAs |
tdbR00000476, tdbR00000807, tdbR00000808, tdbR00000809, tdbR00000810, tdbR00000811, tdbR00000812, tdbR00000813, tdbR00000814, tdbR00000815, tdbR00000816, tdbR00000817, tdbR00000818, tdbR00000819
|
| Publications |
- Valine tRNA levels and availability regulate complex I assembly in leukaemia.
Palaniraja Thandapani, Andreas Kloetgen, Matthew T Witkowski, Christina Glytsou, Anna K Lee, Eric Wang, Jingjing Wang, Sarah E LeBoeuf, Kleopatra Avrampou, Thales Papagiannakopoulos, Aristotelis Tsirigos, Iannis Aifantis
Nature
volume: 601
issue: 7893
epub: Dec. 22, 2021
PUBMED ID: 34937946
DOI: 10.1038/s41586-021-04244-1
|
