Val-AAC, Val-UAC, Val_CAC, melanoma

Gene	Val-AAC, Val-UAC, Val_CAC
Disease	melanoma
Description	VARS-mediated charging of tRNAVal facilitates efficient translation of Val-rich transcripts, e.g. those encoding key enzymes in fatty acid oxidation, which therapy resistant melanoma cultures depend on for their survival
tRNAs	tdbR00000476, tdbR00000807, tdbR00000808, tdbR00000809, tdbR00000810, tdbR00000811, tdbR00000812, tdbR00000813, tdbR00000814, tdbR00000815, tdbR00000816, tdbR00000817, tdbR00000818, tdbR00000819
Publications	Valine aminoacyl-tRNA synthetase promotes therapy resistance in melanoma. Najla El-Hachem, Marine Leclercq, Miguel Susaeta Ruiz, Raphael Vanleyssem, Kateryna Shostak, Pierre-René Körner, Coralie Capron, Lorena Martin-Morales, Patrick Roncarati, Arnaud Lavergne, Arnaud Blomme, Silvia Turchetto, Eric Goffin, Palaniraja Thandapani, Ivan Tarassov, Laurent Nguyen, Bernard Pirotte, Alain Chariot, Jean-Christophe Marine, Michael Herfs, Francesca Rapino, Reuven Agami, Pierre Close Nature cell biology volume: 26 issue: 7 epub: June 7, 2024 PUBMED ID: 38849541 DOI: 10.1038/s41556-024-01439-2